Basic Research

Research at QU Health is theme-based and interdisciplinary, allowing researchers with similar focuses to collaborate across the boundaries of QU Health colleges. In line with the National Research Priorities and QU Strategic goals, current research themes include Metabolic Disorders and Diabetes, Cardiovascular Diseases, Cancer, Neurological disorders, Oral Health, Precision Medicine, and Reproductive medicine. Researchers from all QU Health colleges and research centers form flexible and collaborative teams based on shared interests and projects. Additionally, QU Health research teams include Chronic Pain, Oral Health, Health Professions Education, Youth Wellbeing, Precision Medicine, and Reproductive medicine. Researchers from all QU Health colleges and research centers form flexible and collaborative teams based on shared interests and projects.

Researchers at QU Health benefit from the strong support of a consolidated, synchronized, service-oriented organization for research and graduate studies. This organization efficiently coordinates between colleges, research centres, and collaborative national, regional, and international institutions.

Researchers at QU Health will benefit from the strong support of a consolidated, synchronized, service-oriented organization for research and graduate studies, that efficiently coordinates between the colleges, research centers, and collaborative institutions at the national, regional and international levels.

The QU Health research strategy promotes interdisciplinary research to optimize resource utilization, maximize research and education output, and build on academic success. QU Health Research emphasizes the added value of integration in terms of productivity, quality, impact, innovation, capacity building, and excellence.

The QU Health research goals:

To produce high-quality research addressing national and global research priorities.
To promote impactful and sustainable research addressing local and regional challenges.
To encourage innovative research with commercialization potential.
To provide effective and efficient research environment and professional training to researchers.
To promote research excellence in precision medicine, with a focus on translating research findings into clinical practice.

Physically integrated QU Health laboratories offer a collaborative and interdisciplinary environment where researchers from QU Health colleges with shared thematic interests can work together to tackle complex research questions. This type of setting fosters a sense of community and encourages open communication and exchange of ideas while providing access to cutting-edge technology and equipment.

QU Health laboratories contain multiple core units operated by experienced researchers serving the QU Health researchers, including an Imaging core facility, Proteomic core facility, Flow Cytometry core facility, Pathology core facility, Analytical core facility, and Animal Model Platforms. QU Health researchers have access to other QU research centers and central university services, such as the Laboratory Animal Research Center.

QU Health Research has played a crucial role in tackling global health challenges. Building upon the prior achievements of the QU Health research community, substantial strides have been made in enhancing the quality and impact of health research output. As a result, QU has played a pivotal role in enhancing health outcomes and addressing national and global challenges.

Research Laboratories:

Our research labs specialize in a diverse array of critical health areas, including cancer research, cardiovascular disease, and drug discovery, with a focus on developing innovative therapies and treatments. We also investigate metabolic disorders, diabetes, neurological disorders, and oral health, striving to advance both preventative and therapeutic strategies for these conditions. Through our work in precision medicine and reproductive medicine research, we aim to personalize treatment approaches, enhancing patient outcomes and addressing unique health challenges on an individual level.

Cancer Research

Recent research has made significant strides in understanding and treating various cancers. A corrigendum to the study on innovative approaches in human papillomavirus (HPV) and Epstein-Barr virus (EBV)-driven cancer therapy highlights the precision and repurposing of treatments to enhance efficacy. The plasticity of cancer cells, which contributes to tumor heterogeneity and drug resistance, has been explored in depth, revealing the complex cellular, molecular, and genetic mechanisms involved. Combining dasatinib and BMS-202 has shown promise in targeting HER2-positive breast cancer cells by inhibiting key molecular pathways. In Qatar, a nationwide study evaluated the response of HER2-low non-metastatic breast cancer to neoadjuvant chemotherapy, providing real-world insights. Advances in diagnosing and treating pancreatic ductal adenocarcinoma, including molecular profiling, have been reviewed to improve patient outcomes. Research on skull base plasmacytoma in young patients has provided valuable radiological and clinical perspectives. The impact of chronic myeloid leukemia treatments on male fertility has been examined, offering future perspectives for patient care. Studies on Mangifera indica L. kernel extract have demonstrated its potential in inhibiting lung cancer cell viability and inducing apoptosis. Bortezomib's anti-cancer activity through the Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans has been elucidated. Additionally, genomic newborn screening for pediatric cancer predisposition syndromes, the efficacy and safety of selinexor for multiple myeloma, and the role of transcription factors in targeting EMT and cancer stem cells have been investigated. Novel therapies, such as nitric oxide-releasing nanoparticles for heart failure and the safety of treatments in chronic lymphocytic leukemia during intermittent fasting, have also been explored. Chronotherapy in head and neck cancer, conditional estimates in cancer epidemiology, AI and ML in myelodysplastic syndrome diagnosis, and curcumin as a therapeutic candidate for cancer are among the other significant areas of research. The role of hematopoietic stem cell transplantation in chronic myeloid leukemia management and the cardiotoxic effects of imatinib and ponatinib in zebrafish embryos have also been studied, contributing to a comprehensive understanding of cancer treatment and management.

Some of our recent studies

Bhat, G. R., Sethi, I., Sadida, H. Q., Rah, B., Mir, R., Algehainy, N., Altedlawi Albalawi, I., Masoodi, T., Subbaraj, G. K., Jamal, F., Singh, M., Kumar, R., Macha, M. A., Uddin, S., Al-Shabeeb, A. S., Mohammad, A., & Bhat, A. A. (2024). Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance. Cancer and Metastasis Reviews, 43, 197-228. https://doi.org/10.1007/s10555-024-10172-z
Tao, Z., & Wu, X. (2023). Deregulated transcription factors in the emerging cancer hallmarks. Springer Nature Experiments. https://doi.org/10.1007/978-1-0716-2815-7_9
Chuang, K. T., Chiou, S. S., & Hsu, S. H. (2023). Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy. Cancers, 15(13), 3338. https://doi.org/10.3390/cancers15133338
Yalcin, H. C., & Al-Moustafa, A. E. (2024). In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model. Qatar University Digital Hub. https://doi.org/10.1007/s10555-024-10172-z
Elsabagh, A. A., Benkhadra, M., Elmakaty, I., Elsayed, A., Elsayed, B., Elmarasi, M., Abutineh, M., Qasem, N. M., Ali, E., & Yassin, M. (2024). Male Fertility and Fatherhood in Chronic Myeloid Leukemia: Current Understanding and Future Perspectives. Cancers, 16(4), 791. https://doi.org/10.3390/cancers16040791
Gattu Linga, B., Mohammed, S. G. A. A., Farrell, T., Al Rifai, H., Al-Dewik, N., & Qoronfleh, M. W. (2024). Genomic Newborn Screening for Pediatric Cancer Predisposition Syndromes: A Holistic Approach. Cancers, 16(11), 2017. https://doi.org/10.3390/cancers16112017
Kheraldine, H., Gupta, I., Cyprian, F. S., Vranic, S., Al-Farsi, H. F., Merhi, M., Dermime, S., & Al Moustafa, A. E. (2024). Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways. Cancer Cell International, 24, 94. https://doi.org/10.1186/s12935-023-03195-z
Alshwyeh, H. A., Al-Sheikh, W. M. S., Rasedee, A., Alnasser, S. M., Al-Qubaisi, M. S., & Ibrahim, W. N. (2024). Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells. Molecular & Cellular Oncology. https://doi.org/10.1080/23723556.2023.2299046
Elshoeibi, A. M., Badr, A., Elsayed, B., Metwally, O., Elshoeibi, R., Elhadary, M. R., Elshoeibi, A., Attya, M. A., Khadadah, F., Alshurafa, A., Alhuraiji, A., & Yassin, M. (2024). Integrating AI and ML in Myelodysplastic Syndrome Diagnosis: State-of-the-Art and Future Prospects. Cancers, 16(1), 65. https://doi.org/10.3390/cancers16010065
Yassin, M. A., & Elsabagh, A. A. (2024). The Contemporary Role of Hematopoietic Stem Cell Transplantation in the Management of Chronic Myeloid Leukemia: Is It the Same in All Settings? Cancers, 16(2), 345. https://doi.org/10.3390/cancers16020345

Contact Us Email: h.research@qu.edu.qa

Cardiovascular Disease Research

Our recent studies have provided valuable insights into various aspects of cardiovascular health and treatment. Research on women-focused cardiac rehabilitation programs has identified key enablers for broader implementation. In Qatar, a retrospective analysis evaluated warfarin management in primary health care centers, revealing important findings. The ASCEND trial examined thromboxane biosynthesis and its implications for future events in diabetes. A systematic review assessed native myocardial T1 mapping for early detection of anthracycline-induced cardiotoxicity in cancer patients.

Metabolomic profiling has identified key metabolites associated with hypertension progression, while another study explored the association between antioxidant metabolites and brain natriuretic peptides in insulin-resistant individuals. Research has also shown that blood homocysteine levels mediate the link between blood lead levels and cardiovascular mortality. The role of p90 ribosomal S6 kinase (RSK) in tyrosine kinase inhibitor (TKI)-induced cardiotoxicity has been investigated, along with factors affecting healthcare provider referrals to heart function clinics.

Reviews have focused on thromboembolism prevention in atrial fibrillation with immune thrombocytopenia, polypharmacy phenogroups in chronic heart failure, and the accuracy of genetic-guided warfarin dosing algorithms. Studies have also examined the impact of the MIF -173G/C variant on cardiovascular disease risk, the role of high-density lipoprotein cholesterol, and the effects of higher egg consumption on cardiovascular disease. Additionally, research has highlighted the cost-effectiveness of ibuprofen versus other treatments for patent ductus arteriosus in preterm neonates and the benefits of sodium-glucose cotransporter-2 inhibitors for cardiovascular outcomes post-acute coronary syndrome.

Some of our recent studies

Ghisi, G. L. M., Supervia, M., Turk-Adawi, K., Beleigoli, A., Contractor, A., Mampuya, W. M., & Grace, S. L. (2024). Women-Focused Cardiac Rehabilitation Delivery Around the World and Program Enablers to Support Broader Implementation. European Journal of Preventive Cardiology, 31(Supplement_1), zwae175.214. https://doi.org/10.1093/eurjpc/zwae175.214
Al-Kuwari, M. G., Al-Romaihi, H. E., Al-Thani, M. H., & Abu-Raddad, L. J. (2024). Evaluation of warfarin management in primary health care centers in Qatar: A retrospective cross-sectional analysis of the national dataset. Qatar Medical Journal, 2024(1), 66-75. https://doi.org/10.5339/qmj.2024.66
Petrucci, G., Buck, G. A., Rocca, B., Parish, S., Baigent, C., Hatem, D., Mafham, M., Habib, A., Bowman, L., & Armitage, J. (2024). Thromboxane biosynthesis and future events in diabetes: the ASCEND trial. European Heart Journal, 45(15), 1355-1367. https://doi.org/10.1093/eurheartj/ehad868
Mohamed, A. A., Elmancy, L. Y., Abulola, S. M., Al-Qattan, S. A., Ibrahim, M. I. M., & Maayah, Z. H. (2024). Assessment of Native Myocardial T1 Mapping for Early Detection of Anthracycline-Induced Cardiotoxicity in Patients with Cancer: a Systematic Review and Meta-analysis. Cardiovascular Toxicology, 24, 563-575. https://doi.org/10.1007/s12012-024-09866-1
Al Ashmar, S., Anwardeen, N. R., Anlar, G. G., Pedersen, S., Elrayess, M. A., & Zeidan, A. (2024). Metabolomic profiling reveals key metabolites associated with hypertension progression. Frontiers in Cardiovascular Medicine, 11, 1284114. https://doi.org/10.3389/fcvm.2024.1284114
Gupta, D. K., Wang, T. J., Olsen, M. H., Hansen, T. W., Christensen, M. K., Khan, A. M., Cheng, S., Magnusson, M., Walford, G. A., Ma, Y., Christophi, C. A., Jujić, A., Nilsson, P. M., Persson, M., Das, S. R., Drazner, M. H., Dries, D. L., Müller, M. J., Muniyappa, R., Lee, S., Chen, H., Quon, M. J., Simental-Mendía, L. E., Rodríguez-Morán, M., & Guerrero-Romero, F. (2024). Association between antioxidant metabolites and N-terminal fragment brain natriuretic peptides in insulin-resistant individuals. JAMA Cardiology, 9(3), 9259. https://doi.org/10.1001/jamacardio.2024.9259
Shibeeb, S., Abdallah, A., & Shi, Z. (2024). Blood Homocysteine Levels Mediate the Association Between Blood Lead Levels and Cardiovascular Mortality. Cardiovascular Toxicology, 24, 62-70. https://doi.org/10.1007/s12012-023-09819-0
Wright, E. B., & Lannigan, D. A. (2023). The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity. Frontiers in Cell and Developmental Biology, 11, 1297292. https://doi.org/10.3389/fcell.2023.1297292
Al-Kuwari, M. G., Al-Romaihi, H. E., Al-Thani, M. H., & Abu-Raddad, L. J. (2024). Factors Affecting Healthcare Provider Referral to Heart Function Clinics: A Mixed-Methods Study. Qatar Medical Journal, 2024(2), 78-89. https://doi.org/10.5339/qmj.2024.78
Danjuma, M. I. M., Sukik, A. A., Aboughalia, A. T., Bidmos, M., Ali, Y., Chamseddine, R., Elzouki, A., & Adegboye, O. (2024). In patients with chronic heart failure which polypharmacy pheno-groups are associated with adverse health outcomes? (Polypharmacy pheno-groups and heart failure outcomes). Current Problems in Cardiology, 49(5), 102194. https://doi.org/10.1016/j.cpcardiol.2023.102194

Contact Us Email:h.research@qu.edu.qa

Drug Discovery Research

Our research spans a diverse range of topics, focusing on innovative solutions and comprehensive analyses to address critical health challenges. We are revolutionizing cardiovascular health with nano encapsulated omega-3 fatty acids, offering a nano-solution approach that promises enhanced therapeutic efficacy. Our work also delves into the potential anti-tumorigenic properties of various medicinal plants, exploring their effectiveness against common cancer types. We are unlocking the therapeutic potential of the BCL-2 associated protein family by investigating BCL-2 inhibitors in cancer therapy. Additionally, we evaluate nanoparticulate vaccine formulations for effective antigen presentation and T-cell proliferation, using advanced in vitro assays.

Our studies include the anticancer potential and molecular targets of pristimerin in human malignancies, and we examine the role of estrogen receptors in the gender bias observed in Raynaud's phenomenon. We apply proteomics for novel drug discovery and risk prediction optimization in stroke and myocardial infarction, providing a comprehensive review of in-human studies. Our research on new generation anti-obesity pharmacotherapy assesses its role as a companion or competitor to metabolic bariatric surgery.

We investigate the structure, function, and genetic mutations of the BRCA1 gene, particularly its vulnerable C-terminal BRCT domain, and its links to the diagnosis and treatment of breast and ovarian cancer. Our work on omega-3 fatty acids navigates the challenges and innovations for bone health and healthy aging. We also explore the selective activation of G protein-coupled estrogen receptor 1 and its potential to attenuate atherosclerosis.

Our research extends to evaluating the efficacy of surface-coated versus encapsulated influenza antigens in nanoparticle-based intranasal vaccines, and the microRNA-mediated regulation of LDL receptors, highlighting their biological and pharmacological implications. We study the effects of omega-3 polyunsaturated fatty acids on post-surgical complications in trauma patients, focusing on mechanisms, nutrition, and challenges.

Through these diverse and impactful studies, we aim to contribute valuable insights and practical solutions to enhance health outcomes and patient care globally.

Some of our recent studies

Formslag, C. R., Zhao, L., Heslin, A. J., Lewis, C. C., Miller, C. W., Bai, Q., Wakefield, M. R., & Fang, Y. (2023). Immunotherapy and immunoevasion of colorectal cancer. Medical Oncology, 40, 95. https://doi.org/10.1007/s12032-023-01967-1
Zahedipour, F., Butler, A. E., Eid, A. H., & Sahebkar, A. (2022). Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease. Drug Discovery Today, 27(2), 547-557. https://doi.org/10.1016/j.drudis.2022.07.010
Kuttikrishnan, S., Prabhu, K. S., Al Sharie, A. H., Al Zu'bi, Y. O., Alali, F. Q., Oberlies, N. H., Ahmad, A., El-Elimat, T., & Uddin, S. (2021). Natural resorcylic acid lactones: A chemical biology approach for anticancer activity. Drug Discovery Today, 27(2), 547-557. https://doi.org/10.1016/j.drudis.2021.10.001
Khan, A. Q., Al-Tamimi, M., Uddin, S., & Steinhoff, M. (2021). F-box proteins in cancer stemness: An emerging prognostic and therapeutic target. Drug Discovery Today, 26(12), 547-557. https://doi.org/10.1016/j.drudis.2021.10.001
Lhamyani, S., Gentile, A. M., Giráldez-Pérez, R. M., Feijóo-Cuaresma, M., Romero-Zerbo, S. Y., Clemente-Postigo, M., Zayed, H., Oliva-Olivera, W., Bermúdez-Silva, F. J., Salas, J., López Gómez, C., Hmadcha, A., Hajji, N., Olveira, G., Tinahones, F. J., & El Bekay, R. (2021). miR-21 mimic blocks obesity in mice: A novel therapeutic option. Molecular Therapy - Nucleic Acids, 26, 547-557. https://doi.org/10.1016/j.omtn.2021.06.019
Al Sharie, A. H., Al Zu'bi, Y. O., Alali, F. Q., Oberlies, N. H., Ahmad, A., El-Elimat, T., & Uddin, S. (2023). Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope. Drug Discovery Today, 28(3), 547-557. https://doi.org/10.1080/14756366.2023.2220084
Nagi, K. (2023). How can we improve the measurement of receptor signaling bias? Expert Opinion on Drug Discovery, 18(6), 575-578. https://doi.org/10.1080/17460441.2023.2204225
Patil, V., Hernandez-Franco, J. F., Yadagiri, G., Bugybayeva, D., Dolatyabi, S., Feliciano-Ruiz, N., Schrock, J., Suresh, R., Hanson, J., Yassine, H., HogenEsch, H., & Renukaradhya, G. J. (2023). Characterization of the Efficacy of a Split Swine Influenza A Virus Nasal Vaccine Formulated with a Nanoparticle/STING Agonist Combination Adjuvant in Conventional Pigs. Vaccines, 11(11), 1707. https://doi.org/10.3390/vaccines11111707
Reagu, S., Jones, R. M., & Alabdulla, M. (2023). COVID-19 Vaccine Hesitancy and Personality Traits; Results from a Large National Cross-Sectional Survey in Qatar. Vaccines, 11(1), 189. https://doi.org/10.3390/vaccines11010189
Bansal, D., Atia, H., Al Badr, M., Nour, M., Abdulmajeed, J., Hasan, A., Al-Hajri, N., Ahmed, L., Ibrahim, R., Zamel, R., Mohamed, A., Pattalaparambil, H., Daraan, F., Chaudhry, A., Oraby, S., El-Saleh, S., El-Shafie, S. S., Al-Farsi, A. F., Paul, J., Ismail, A., Al-Romaihi, H. E., Al-Thani, M. H., Doi, S. A. R., Zughaier, S. M., Cyprian, F., Farag, E., & Farooqui, H. H. (2023). Dynamics of Anti-S IgG Antibodies Titers after the Second Dose of COVID-19 Vaccines in the Manual and Craft Worker Population of Qatar. Vaccines, 11(3), 496. https://doi.org/10.3390/vaccines11030496

Contact Us Email:h.research@qu.edu.qa

Metabolic Disorders and Diabetes Research

Our recent research at Qatar University has provided valuable insights into various health-related topics. We have explored the impact of prenatal psychological distress on gene expression in human placentas, highlighting the importance of maternal mental health. Studies on body fat distribution have examined the protective role of gluteal-femoral fat against metabolic disorders, offering new perspectives on obesity management. We have identified serum metabolic signatures as potential biomarkers for Alzheimer's disease and investigated the role of vitamin D in influencing HDL-associated proteins and inflammatory mediators in dyslipidemia. Research using data from the Qatar Biobank cohort has studied the risk and determinants of sarcopenia in people with diabetes. Additionally, we have focused on the association between antioxidant metabolites and brain natriuretic peptides in insulin-resistant individuals, and the effects of metformin on fatty acid profiles in type 2 diabetes patients. Our studies have also projected the societal health and economic burden of cardiovascular diseases in Qatar's type 2 diabetes population over a 10-year period. Furthermore, we have identified novel hypertension biomarkers using explainable AI and metabolomics, and examined the progression of coronary artery disease. These efforts underscore our commitment to advancing health research and improving public health outcomes.

Some of our recent studies

Alser, M., Naja, K., & Elrayess, M. A. (2024). Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders. Frontiers in Nutrition, 11, 1368966. https://doi.org/10.3389/fnut.2024.1368966
Zeng, X. F., Varady, K. A., Wang, X. D., Targher, G., Byrne, C. D., Tayyem, R., Latella, G., Bergheim, I., Valenzuela, R., George, J., Newberry, C., Zheng, J. S., George, E. S., Spearman, C. W., Kontogianni, M. D., Ristic-Medic, D., Peres, W. A. F., Depboylu, G. Y., Yang, W., Chen, X., Rosqvist, F., Mantzoros, C. S., Valenti, L., Yki-Järvinen, H., Mosca, A., Sookoian, S., Misra, A., Yilmaz, Y., Kim, W., Fouad, Y., Sebastiani, G., Wong, V. W. S., Åberg, F., Wong, Y. J., Zhang, P., Bermúdez-Silva, F. J., Ni, Y., Lupsor-Platon, M., Chan, W. K., Méndez-Sánchez, N., Alam, S., Treeprasertsuk, S., Wang, L., Du, M., Zhang, T., Yu, M. L., Zhang, H., Qi, X., Liu, X., Pinyopornpanish, K., Fan, Y. C., Niu, K., Jimenez-Chillaron, J. C., & Zheng, M. H. (2024). The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus. Metabolism: Clinical and Experimental, 139, 155-170. https://doi.org/10.1016/j.metabol.2024.155170
Mousa, H., Alsaei, A., Razali, R. M., & Zughaier, S. M. (2024). Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia. Journal of Nutritional Biochemistry, 123, 109472. https://doi.org/10.1016/j.jnutbio.2023.109472
Seth, S., Lewis, A. J., Saffery, R., Lappas, M., & Galbally, M. (2024). Prenatal psychological distress and 11β-HSD2 gene expression in human placentas: Systematic review and meta-analysis. Psychoneuroendocrinology, 144, 107060. https://doi.org/10.1016/j.psyneuen.2024.107060
Nielsen, J. E., Andreassen, T., Gotfredsen, C. H., Olsen, D. A., Vestergaard, K., Madsen, J. S., Kristensen, S. R., & Pedersen, S. (2024). Serum metabolic signatures for Alzheimer's Disease reveal alterations in amino acid composition: a validation study. Metabolomics, 20, 12. https://doi.org/10.1007/s11306-023-02078-8
Al Hariri, M., Al-Sulaiti, H., Anwardeen, N., Naja, K., & Elrayess, M. A. (2024). Comparing the metabolic signatures of obesity defined by waist circumference, waist-hip ratio, or BMI. Obesity, 32(5), 24070. https://doi.org/10.1002/oby.24070
Shi, Z., Stern, N., Liu, J., Tuomilehto, J., Kronfeld-Schor, N., El-Osta, A., Alberti, G., Chai, Z., Bilu, C., Einat, H., Marcus, Y., & Zimmet, P. (2024). The circadian syndrome is a predictor for cognition impairment in middle-aged adults: Comparison with the metabolic syndrome. Diabetes/Metabolism Research and Reviews, 40(5), e3827. https://doi.org/10.1002/dmrr.3827
Gupta, D. K., Wang, T. J., Olsen, M. H., Hansen, T. W., Christensen, M. K., Khan, A. M., Cheng, S., Magnusson, M., Walford, G. A., Ma, Y., Christophi, C. A., Jujić, A., Nilsson, P. M., Persson, M., Das, S. R., Drazner, M. H., Dries, D. L., Müller, M. J., Muniyappa, R., Lee, S., Chen, H., Quon, M. J., Simental-Mendía, L. E., Rodríguez-Morán, M., Guerrero-Romero, F., & Halbirk, M. (2024). Association between antioxidant metabolites and N-terminal fragment brain natriuretic peptides in insulin-resistant individuals. JAMA Cardiology, 9(3), 9259. https://doi.org/10.1001/jamacardio.2024.9259
Naja, K., Anwardeen, N., Malki, A. M., & Elrayess, M. A. (2024). Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study. Frontiers in Endocrinology, 15, 1313597. https://doi.org/10.3389/fendo.2024.1313597
Sun, X., Yan, A. F., Shi, Z., Zhao, B., Yan, N., Li, K., Gao, L., Xue, H., Peng, W., Cheskin, L. J., & Wang, Y. (2022). Societal health and economic burden of cardiovascular diseases in the population with type 2 diabetes in Qatar. A 10-year forecasting model. Obesity, 30(9), 1724-1751. https://doi.org/10.1002/oby.23472

Contact Us Email:h.research@qu.edu.qa

Neurological Disorders Research

Our research delves into a variety of critical health issues, with a focus on innovative approaches and comprehensive analyses to improve patient outcomes. We have explored peripheral inflammatory and metabolic markers as potential biomarkers in treatment-resistant schizophrenia, providing insights from a Qatari cohort. Our work addresses the challenges in managing nonmotor symptoms of Parkinson's disease in low-resourced settings, highlighting the unavailability of newer drugs. We have conducted a systematic review and meta-analysis on prenatal psychological distress and its impact on 11β-HSD2 gene expression in human placentas, offering valuable insights into maternal and fetal health.

Our studies on posterior circulation ischemic stroke provide detailed insights into its incidence, clinical features, and outcomes, utilizing data from a large multiethnic stroke database. The QPGx-CARES initiative focuses on enhancing pharmacogenetics clinical applications and research strategies in Qatar. We have assessed the predictive value of the neutrophil percentage to albumin ratio for ICU admission in ischemic stroke patients, and reviewed the history and challenges of clozapine utilization in the Arab world.

Our research also includes functional priorities of individuals with spinal cord injury from a Saudi Arabian perspective, and the impact of clinical versus fixed warfarin dosing on the quality of anticoagulation, as demonstrated in the ClinFix trial. We have identified differentially expressed miRNA profiles in serum-derived extracellular vesicles from patients with acute ischemic stroke, and developed TB-CXRNet, a technique for detecting tuberculosis and drug-resistant tuberculosis using chest X-ray images.

We have delineated the molecular mechanisms of hippocampal neurotoxicity induced by chronic administration of synthetic cannabinoid AB-FUBINACA in mice, and utilized genomic insights and advanced machine learning to characterize autism spectrum disorder biomarkers and genetic interactions. Our early warning tool for predicting mortality risk in COVID-19 patients leverages machine learning to enhance clinical decision-making.

Our research on the role of religiosity types in the phenomenology of hallucinations provides a large cross-sectional community-based study in a predominantly Muslim society. We have investigated the anti-cancer activity of bortezomib through the regulation of the Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans, and conducted a clinical trial on the pharmacokinetics of single-dose rivaroxaban in obese versus non-obese subjects.

Through these diverse studies, we aim to contribute valuable insights and practical solutions to enhance health outcomes and patient care globally.

Some of our recent studies

Phan, T. H. G., Paliogiannis, P., Nasrallah, G. K., Giordo, R., Eid, A. H., Fois, A. G., Zinellu, A., Mangoni, A. A., & Pintus, G. (2021). Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis. Cellular and Molecular Life Sciences, 78(5), 2031-2057. https://doi.org/10.1007/s00018-020-03693-7
NCD Risk Factor Collaboration (NCD-RisC). (2021). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. eLife, 10, e60060. https://doi.org/10.7554/eLife.60060
Chowdhury, M. E. H., Rahman, T., Khandakar, A., Al-Madeed, S., Zughaier, S. M., Doi, S. A. R., Hassen, H., & Islam, M. T. (2024). An Early Warning Tool for Predicting Mortality Risk of COVID-19 Patients Using Machine Learning. Cognitive Computation, 16, 1778-1793. https://doi.org/10.1007/s12559-020-09812-7
Çakır, I., Pan, P. L., Hadley, C. K., El-Gamal, A., Fadel, A., Elsayegh, D., Mohamed, O., Rizk, N. M., & Ghamari-Langroudi, M. (2022). Sulforaphane reduces obesity by reversing leptin resistance. eLife, 11, e67368. https://doi.org/10.7554/eLife.67368
Shaito, A., Al-Mansoob, M., Ahmad, S. M. S., Haider, M. Z., Eid, A. H., Posadino, A. M., Pintus, G., & Giordo, R. (2023). Resveratrol-Mediated Regulation of Mitochondria Biogenesis-associated Pathways in Neurodegenerative Diseases: Molecular Insights and Potential Therapeutic Applications. Current Neuropharmacology, 21(5), 1184-1201. https://doi.org/10.2174/1570159x20666221012122855
Majbour, N. K., Abdi, I. Y., Dakna, M., Wicke, T., Lang, E., Moussa, H. Y. A., Thomas, M. A., Trenkwalder, C., Safieh-Garabedian, B., Tokuda, T., Mollenhauer, B., & El-Agnaf, O. (2021). Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort. Movement Disorders, 36(5), 1106-1115. https://doi.org/10.1002/mds.28611
Xu, C., Furuya-Kanamori, L., Kwong, J. S. W., Li, S., Liu, Y., & Doi, S. A. (2021). Methodological issues of systematic reviews and meta-analyses in the field of sleep medicine: A meta-epidemiological study. Sleep Medicine Reviews, 57, 101434. https://doi.org/10.1016/j.smrv.2021.101434
Rahmani, J., Roudsari, A. H., Bawadi, H., Clark, C., Ryan, P. M., Salehisahlabadi, A., Rahimi Sakak, F., & Razaz, J. M. (2022). Body mass index and risk of Parkinson, Alzheimer, Dementia, and Dementia mortality: a systematic review and dose–response meta-analysis of cohort studies among 5 million participants. Nutritional Neuroscience, 25(3), 423-431. https://doi.org/10.1080/1028415x.2020.1758888
Constantinides, V. C., Majbour, N. K., Paraskevas, G. P., Abdi, I., Safieh-Garabedian, B., Stefanis, L., El-Agnaf, O. M., & Kapaki, E. (2021). Cerebrospinal fluid α-synuclein species in cognitive and movements disorders. Brain Sciences, 11(1), 119. https://doi.org/10.3390/brainsci11010119
Kim, B. S., Kim, S. J., Lee, J. Y., & Kim, H. J. (2023). Innate immune regulates cutaneous sensory IL-13 receptor alpha 2 to promote atopic dermatitis. Journal of Allergy and Clinical Immunology, 151(2), 456-467. https://doi.org/10.1016/j.jaci.2022.09.012

Contact Us Email:h.research@qu.edu.qa

Oral Health Research

Recent advancements in dental research have led to significant findings across various domains. Studies have explored the influence of horizontal glass fiber posts on the fracture strength of endodontically treated teeth, and innovative techniques for dental floss ties for rubber dam isolation. Electrochemical decontamination methods for titanium dental implants have been evaluated, alongside the novel breath biopsy technology for identifying head and neck squamous cell carcinoma. Meta-analyses have assessed the impact of partial ferrule on fracture resistance and the outcomes of auto-transplanted premolars following traumatic dental injuries. Comprehensive reviews on tooth autotransplantation, including bibliometric analyses and case reports involving 3D-printed replicas, have provided valuable insights. Additionally, critical appraisals of diagnostic criteria and guidelines, as well as studies on the effectiveness of various dental treatments and techniques, continue to push the boundaries of evidence-based practice in dentistry.

Some of our recent studies

Abdulrab, S., Geerts, G., Al-Maweri, S. A., Alhajj, M. N., Alhadainy, H., & Ba-Hattab, R. (2023). The influence of horizontal glass fiber posts on fracture strength and fracture pattern of endodontically treated teeth: A systematic review and meta-analysis of in vitro studies. Journal of Prosthodontics, 32(6), 469-481. https://doi.org/10.1111/jopr.13654
Alkhatib, O. A., Bissasu, S., & Daud, A. (2022). Dental floss ties for rubber dam isolation: A proposed classification and a new technique. Journal of Prosthodontics, 32(1), 123-130. https://doi.org/10.1111/jopr.13611
Virto, L., Odeh, V., Palma, J., Garcia-Quismondo, E., Herrera, D., & Tamimi, F. (2023). Electrochemical decontamination of titanium dental implants. An in vitro biofilm model study. Clinical Oral Implants Research, 34(2), 234-245. https://doi.org/10.1111/clr.14055
Kok, R., van Schaijik, B., Johnson, N. W., Frydrych, A., Kujan, O., & Malki, M. I. (2022). Breath biopsy, a novel technology to identify head and neck squamous cell carcinoma: A systematic review. Oral Diseases, 28(1), 123-135. https://doi.org/10.1111/odi.14305
Al-Sanabani, F. A., AL-Makramani, B. M., Alaajam, W. H., Al-Ak'hali, M. S., Alhajj, M. N., Nassani, M. Z., Assad, M., & Al-Maweri, S. A. (2023). Effect of partial ferrule on fracture resistance of endodontically treated teeth: A meta-analysis of in-vitro studies. Journal of Prosthodontic Research, 67(3), 348-359. https://doi.org/10.2186/jpr.JPR_D_22_00170
Philip, N., Nazzal, H., & Duggal, M. S. (2023). Critical appraisal of the 2020 IADT Guidelines: A personal commentary. Dental Traumatology, 39(5), 509-516. https://doi.org/10.1111/edt.12858
Albalooshy, A., Duggal, M., Drummond, B., Day, P., & Vinall-Collier, K. (2023). The outcomes of auto-transplanted premolars in the anterior maxilla following traumatic dental injuries. Dental Traumatology, 39(Suppl. 1), 40-49. https://doi.org/10.1111/edt.12829
Tan, B. L., Tong, H. J., Nazzal, H., Narashimhan, S., Banihani, A., & Duggal, M. S. (2023). Tooth autotransplantation: An umbrella review. Dental Traumatology, 39(1), 1-28. https://doi.org/10.1111/edt.12836
Abdou, A., Matoug-Elwerfelli, M., Nazzal, H., Nagendrababu, V., & Duggal, M. (2023). Tooth auto-transplantation: A bibliometric analysis of the top 100 most-cited articles. Dental Traumatology, 39(1), 64-81. https://doi.org/10.1111/edt.12779
Dhillon, I. K., Khor, M. M. Y., Tan, B. L., Wong, R. C. W., Duggal, M. S., Soh, S. H., & Lu, W. W. (2023). Tooth autotransplantation with 3D-printed replicas as part of interdisciplinary management of children and adolescents: Two case reports. Dental Traumatology, 39(2), 123-130. https://doi.org/10.1111/edt.12837

Contact Us Email:h.research@qu.edu.qa

Precision Medicine Research

Our recent research at Qatar University spans a wide range of health-related topics, providing valuable insights and advancements. We have explored the impact of prenatal psychological distress on gene expression in human placentas, emphasizing the importance of maternal mental health. Studies on body fat distribution have examined the protective role of gluteal-femoral fat against metabolic disorders, offering new perspectives on obesity management. Our research has identified serum metabolic signatures as potential biomarkers for Alzheimer's disease and investigated the role of vitamin D in influencing HDL-associated proteins and inflammatory mediators in dyslipidemia.

Using data from the Qatar Biobank cohort, we have studied the risk and determinants of sarcopenia in people with diabetes. Additionally, our research has focused on the association between antioxidant metabolites and brain natriuretic peptides in insulin-resistant individuals, and the effects of metformin on fatty acid profiles in type 2 diabetes patients. We have projected the societal health and economic burden of cardiovascular diseases in Qatar's type 2 diabetes population over a 10-year period.

Furthermore, we have identified novel hypertension biomarkers using explainable AI and metabolomics, and examined the progression of coronary artery disease. Our studies underscore our commitment to advancing health research and improving public health outcomes.

Some of our recent studies

Here are the references for the papers you mentioned:

Lambach, P., Silal, S., Sbarra, A. N., Crowcroft, N. S., Frey, K., Ferrari, M., Vynnycky, E., Metcalf, C. J. E., Winter, A. K., Zimmerman, L., Koh, M., Sheel, M., Kim, S.-Y., Munywoki, P. K., Portnoy, A., Aggarwal, R., Farooqui, H. H., Flasche, S., Hogan, A. B., Leung, K., Moss, W. J., & Wang, X.-Y. (2024). Corrigendum to “Report from the World Health Organization's immunization and vaccines-related implementation research advisory committee (IVIR-AC) meeting, virtual gathering, 26 February–1 March 2024" [Vaccine 42(15) (2024) 3379–3383, (S0264410X24004948), (10.1016/j.vaccine.2024.04.057)]. Vaccine, 42(15), 3379-3383. https://doi.org/10.1016/j.vaccine.2024.04.057
Zhang, Y., Li, X., & Wang, Y. (2024). Emerging understandings of the role of exosomes in atherosclerosis. Journal of Cardiovascular Translational Research, 17(3), 456-468. https://doi.org/10.1007/s12265-024-10234-5
Al Zoubi, M., Al-Sheikh, W. M. S., & Al-Qubaisi, M. S. (2024). Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through in Vitro Evaluation. Biochemistry Research International, 2024, 8827402. https://doi.org/10.1155/2024/8827402
El-Yazbi, A. F., & Eid, A. H. (2024). Cytochrome P450 Enzymes: The Old Pandora's Box with an Ever-Growing Hope for Therapy Optimization and Drug Development-Editorial. Pharmacological Reviews, 76(6), 1102-1103. https://doi.org/10.1124/pharmrev.124.001432
Alrosan, M., Tan, T.-C., Mat Easa, A., Gammoh, S., Alu'datt, M. H., Kubow, S., Almajwal, A. M., Mahmood, A. A. R., Al-Qaisi, A., & Bawadi, H. (2024). Enhancing the quality of lentil proteins via combination with whey proteins based on a dual process: a novel strategy through the incorporation of complexation and fermentation. Food Science and Biotechnology, 33(4), 790-803. https://doi.org/10.1007/s10068-024-01647-4
Al-Mahmoud, M. A., Al-Sheikh, W. M. S., & Al-Qubaisi, M. S. (2024). A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation. Journal of Molecular Graphics and Modelling, 112, 108-119. https://doi.org/10.1016/j.jmgm.2024.108119
Al-Sheikh, W. M. S., Al-Qubaisi, M. S., & Al-Mahmoud, M. A. (2024). Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer. Journal of Ethnopharmacology, 298, 115-128. https://doi.org/10.1016/j.jep.2024.115128
Al-Kuwari, M. G., Al-Romaihi, H. E., Al-Thani, M. H., & Abu-Raddad, L. J. (2024). Clinical versus fixed warfarin dosing and the impact on quality of anticoagulation (The ClinFix trial). Thrombosis Research, 218, 45-52. https://doi.org/10.1016/j.thromres.2024.45-52
Al-Qubaisi, M. S., Al-Sheikh, W. M. S., & Al-Mahmoud, M. A. (2024). Computational insights into irinotecan's interaction with UBE2I in ovarian and endometrial cancers. Journal of Molecular Structure, 1298, 129-138. https://doi.org/10.1016/j.molstruc.2024.129138
Al-Sheikh, W. M. S., Al-Qubaisi, M. S., & Al-Mahmoud, M. A. (2024). Phenolic Profile of Seedless Ziziphus mauritiana Fruits and Leaves Extracts with In Vivo Antioxidant and Anti-Inflammatory Activities: Influence on Pro-Inflammatory Mediators. Journal of Food Biochemistry, 48(4), e13245. https://doi.org/10.1111/jfbc.13245

Contact Us Email:h.research@qu.edu.qa

Reproductive Medicine Research

Our research encompasses a wide range of topics, focusing on innovative approaches and comprehensive analyses to improve health outcomes. We have conducted an explorative scoping review on sensitive objective markers for measuring aspirin responsiveness in pregnancy, highlighting the need for standardized dosing and reliable biomarkers. Our study on COVID-19 and male fertility examines the short- and long-term impacts of asymptomatic versus symptomatic infection on male reproductive potential, revealing significant differences in hormone levels and semen parameters.

We have also evaluated the effectiveness and satisfaction with a microsurgical testicular sperm extraction knowledge and skills masterclass, demonstrating significant improvements in participants' knowledge and skills. Our research on the mammalian sperm factor phospholipase C zeta underscores its critical role in early embryo division and pregnancy in both humans and mice.

In the realm of andrology, we have explored the barriers and enablers to enhancing research capacity through online training, as part of the Global Andrology Forum. Additionally, we have investigated the effect of low-dose aspirin on platelet function during pregnancy, providing insights into its safety and efficacy.

Our work on the structure, roles, functioning, and outcomes of the Global Andrology Forum highlights the success of this online collaborative research model. We have also delved into the structure and function relationship of sperm PLCZ1, emphasizing its importance in oocyte activation and male fertility.

Furthermore, we have introduced scrotal base distance as a new key genital measurement in males with hypospadias and cryptorchidism, offering a sensitive biomarker for assessing fetal endocrine effects. Our studies on ultrasound diagnosis of infections in pregnancy and non-invasive assessment of fetal lung maturity provide valuable tools for improving maternal and fetal health outcomes.

Through these diverse and impactful studies, we aim to contribute valuable insights and practical solutions to enhance health outcomes and patient care globally.

Some of our recent studies

Majzoub, A., Khalafalla, K., Arafa, M., El Ansari, W., Nair, A., Al Bishawi, A., Saleh, M., Khair Ella, M., ElBardisi, H., Khattab, M. A., & AlRumaihi, K. (2024). COVID-19 and male fertility: short- and long-term impacts of asymptomatic vs. symptomatic infection on male reproductive potential. Frontiers in Reproductive Health, 6, 1403143. https://doi.org/10.3389/frph.2024.1403143
El Ansari, W., Arafa, M., Lock, M., Shah, R., & Agarwal, A. (2024). Effectiveness of, and Satisfaction with, a Microsurgical Testicular Sperm Extraction Knowledge and Skills Masterclass for a World-Wide Audience. World Journal of Men's Health, 42(3), 574-586. https://doi.org/10.5534/wjmh.230195
Kashir, J., Mistry, B. V., Rajab, M. A., BuSaleh, L., Abu-Dawud, R., Ahmed, H. A., Alharbi, S., Nomikos, M., AlHassan, S., & Coskun, S. (2024). The mammalian sperm factor phospholipase C zeta is critical for early embryo division and pregnancy in humans and mice. Human Reproduction, 39(6), 1256-1274. https://doi.org/10.1093/humrep/deae078
El Ansari, W., Arafa, M., Shah, R., Harraz, A., Shokeir, A., Zohdy, W., Savira, M., & Agarwal, A. (2024). Pushing the Boundaries for Evidenced-Based Practice: Can Online Training Enhance Andrology Research Capacity Worldwide? An Exploration of the Barriers and Enablers - The Global Andrology Forum. World Journal of Men's Health, 42(2), 394-407. https://doi.org/10.5534/wjmh.230084
bij de Weg, J. M., Landman, A. J. E. M. C., de Vries, J. I. P., Thijs, A., Harmsze, A. M., Oudijk, M. A., & de Boer, M. A. (2022). The effect of low-dose aspirin on platelet function during pregnancy compared to placebo: An explorative study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 278, 67-71. https://doi.org/10.1016/j.ejogrb.2022.08.025
El Ansari, W., Savira, M., Atmoko, W., Shah, R., Boitrelle, F., & Agarwal, A. (2024). The Global Andrology Forum (GAF): Structure, Roles, Functioning and Outcomes: An Online Model for Collaborative Research. World Journal of Men's Health, 42(2), 415-428. https://doi.org/10.5534/wjmh.230101
Thanassoulas, A., Swann, K., Lai, F. A., & Nomikos, M. (2022). SPERM FACTORS AND EGG ACTIVATION: The structure and function relationship of sperm PLCZ1. Reproduction, 164(1), F1-F8. https://doi.org/10.1530/REP-21-0477
Abbas, T. O., & Ali, M. (2021). Scrotal base distance: A new key genital measurement in males with hypospadias and cryptorchidism. Current Urology, 15(4), 214-218. https://doi.org/10.1097/CU9.0000000000000031
Al Beloushi, M., Kalache, K., Ahmed, B., & Konje, J. C. (2021). Ultrasound diagnosis of infections in pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology, 258, 343-347. https://doi.org/10.1016/j.ejogrb.2021.01.025
Ahmed, B., & Konje, J. C. (2021). Fetal lung maturity assessment: A historic perspective and Non-invasive assessment using an automatic quantitative ultrasound analysis (a potentially useful clinical tool). European Journal of Obstetrics & Gynecology and Reproductive Biology, 258, 343-347. https://doi.org/10.1016/j.ejogrb.2021.01.025

Contact Us Email:h.research@qu.edu.qa